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Events
Seminar
Bioengineering
Metabolism: The Silent Choreographer of Cellular Tissue Engineering and Regenerative Medicine
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Deepak Nagarath
Deepak Nagrath, Assistant Professor
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Rice Universty - Department of Chemical and Biomolecular Engineering |
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Thursday, November 5, 2009
Time: 4:00 PM
to 5:00 PM
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BRC 282
BioScience Research Collaborative
6500 Main St
Houston, Texas, USA
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My lab’s focus is on systems biology of human diseases. In my lab I am investigating the interplay between cells, matrix support materials, growth factor signals, and metabolism to develop new tissue equivalents and recondition damaged or dying organs. In my talk I will focus on: (1) modulation of cellular metabolism in adipocytes (“fat storing cells”) to generate cell secreted natural extracellular matrix, (2) development of biomedical devices such as bio-artificial livers using cocultures of adipocytes-hepatocytes, (3) systematic differentiation of embryonic stem cells (ESCs) into liver cells, and (4) metabolic adaptations and alterations in chronic diseases such as cancer, AIDS, liver cirrhosis. I am using systems approach combining metabolomics, proteomics, and genomics to characterize the evolution of the metabolic states of the key diseases, as well as elucidate the regulatory mechanisms. Furthermore, my goal using cellular and tissue engineering is to determine the best therapeutic targets to alleviate these metabolic derangements, which will yield therapies combining both nutrition and more conventional drugs that modulate the regulation of the response. In summary my lab focus is on using state-of-the-art cellular and tissue engineering tools with novel metabolic approaches to solve clinical problems. |
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